Yes, the liver is where Modalert (modafinil) is mostly broken down. Once the medication is taken in, it is changed by enzymes in the liver, especially those in the cytochrome P450 system, which includes CYP3A4 and CYP2C19. These enzymes break down modafinil into metabolites that are not active. The body mostly gets rid of these metabolites through pee. While the liver is an important ... https://www.medzsquare.com/au/modalert-200