There's a launch of norepinephrine in the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors while in the dorsal horn to lessen afferent pain transmission and produce analgesia. Consequently, medications like clonidine that target alpha-two receptors can influence the transmission of discomfort. Clonidine is dispersed in breast milk; caution https://altbookmark.com/story21556184/onolidine-no-further-a-mystery