Conolidine’s analgesic consequences stem from its conversation with non-opioid pain pathways. In contrast to opioids, which bind to µ-opioid receptors from the central nervous system, conolidine modulates alternate molecular targets. A Science Advances review observed that conolidine interacts Using the atypical chemokine receptor ACKR3/CXCR7, which regulates opioid peptide availability. https://charliepfpcm.blogs100.com/38556047/alternative-natural-pain-relief-to-replace-traditional-painkillers-secrets